Ameriac's metropolitan areas have driven growth through the economic expansion, creating jobs and prosperity with their policy choices and their industrial, workforce, and innovation assets. The Milken Institute's Best-Performing Cities(BPC) index provides an objective benchmark for examining underlying factors for and identifying unique characteristics of economic growth in successful regions. Our index uses an outcomes-based set of metrics such as job creaton, wage gains, ans technological developments to evaluate the relative growth of metropolitan areas. While national and international political and economice forces beyond a region's control can affect near-term performance, the top-performing metros have cohesive strategies that allow them to leverage their assets more effectively. They offer important lessons that may be helpful to peer regions.