The Regional Digital Trade Integration Index (RDTII)?Guide?2nd edition, prepared by ESCAP in close collaboration with?ECA and ECLAC, serves as a handbook designed to assist policymakers and policy researchers in analysing digital trade regulations. The?Guide?provides essential explanations of the structure of the?RDTII?2.0 framework, a multidimensional cross-economy index of digital trade regulatory integration?utilized by ESCAP, ECA, and ECLAC for digital trade regulatory analysis. It introduces the indicators of digital trade?policy?environment used in the framework, discusses policy implications, and suggests related sources of information.?