Artificial intelligence (AI) has the potential to become a transformative general-purpose technology, reshaping economic, social, and institutional frameworks globally. The Inter-American Development Bank Group (IDBG) recognizes the urgency of fostering AI adoption in Latin America and the Caribbean to catalyze productivity, inclusion, and sustainable development. This document provides a high-level strategic framework to guide IDBGs interventions in advancing AI adoption and responsible use across the region. The document reviews key challenges facing the three dimensions of AI institutions and governance; data and infrastructure; and human capital and how to overcome these challenges to build AI ecosystems and accelerate innovation and adoption in both the public and private sectors. By addressing structural barriers such as uneven digital infrastructure, limited data availability, and insufficient skills, this framework seeks to create conditions for ambitious and equitable AI diffusion. Additionally, it prioritizes a research agenda targeting the impacts, obstacles, and governance of AI adoption, focusing on evidence-based policy design to leapfrog development challenges while mitigating risks of inequality and misuse. This strategic guidance aligns with the three core objectives of IDBImpact: reducing poverty and inequality, addressing climate change, and fostering sustainable regional growth.