Current climate action is falling short of meeting global climate goals. To get back on track, action is needed at all levels. Place-based climate action ? i.e. policies targeted or tailored to the circumstances of different places ? can work with the grain of local markets, leverage the funding and powers of sub-national governments and mobilise local communities to deliver meaningful change. This paper reviews the case for place-based climate policies and actions and outlines challenges and opportunities in four key policy areas: supporting the transition of businesses and workforces to net zero; investing in climate-resilient infrastructure; stimulating climate innovation; and enhancing financing for place-based climate action. Additionally, it outlines a framework for place-based climate action by sub-national governments.