Technological innovation has successfully permitted the safe and effective performance of some surgical procedures in lower-cost ambulatory surgery centers (ASCs) in place of the hospital inpatient setting. Concurrently, policy experts and the US Congress have proposed adopting site-neutral payment (ie, paying the same amount for a service regardless of where it is performed) to promote safe and cost-effective care, with the Committee for Responsible Federal Budget estimating that site-neutral payment could save $153 billion over a decade. As procedural innovation advances, specialties can optimize procedures to improve quality, safety, and lower cost: ophthalmology is no exception.