Digital trade has been fueling global economic growth. While the significance of the regulatory environment is increasingly acknowledged, empirical evidence on its trade effects remains limited―particularly within the Asia-Pacific context. Drawing on the Asia-Pacific Regional Digital Trade Integration Index 2.0 (RDTII 2.0), developed by the United Nations Economic and Social Commission for Asia and the Pacific (ESCAP) in 2024, this study conducts a regionally grounded and domain-comprehensive analysis across 22 economies and 12 distinct policy areas. Structural gravity models are employed to estimate the effects of both domestic regulation and inter-economy regulatory convergence on trade in ICT goods and digitally deliverable services. A synthetic model integrating elastic net, random forests, and extreme gradient boosting, optimized via nested cross-validation, further uncovers the political economy dynamics underlying regulatory configurations. The results reveal that restrictive regulation significantly curtails digital trade across most policy domains, with identified domains exerting markedly stronger effects. Although regulatory convergence generally enhances trade, its effect is conditional on the domestic regulatory context, which itself appears to reflect a hybrid logic shaped by both political accountability and economic development. These findings advance the global understanding of digital trade governance through an Asia-Pacific lens, offering timely insights for researchers and policymakers seeking to align domestic reform with international cooperation in the digital era.