Bioeconomy is emerging as a new development paradigm and holds transformative potential for the Amazon region in Brazil. This report explores how bioeconomy can drive sustainable development in the Amazon, balancing economic development, environmental protection, and the inclusion of local communities. It presents the Brazilian approach to bioeconomy in a comparative perspective and identifies policy recommendations for Brazil, other Amazonian countries, and the international community to advance sustainable development. It emphasises how science, technology, innovation, and traditional knowledge can shape sustainable futures in the Amazon and beyond.